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Yeast two-hybrid protein-protein interaction studies showed that HCMV pAP (pUL80.5) interacts with itself through a short sequence near its amino end called the …

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This chapter updates earlier reviews on the structure and formation human cytomegalovirus (HCMV) virions (Gibson 1996, 2006; Eickmann et al. 2006), and complements several other reviews on herpesvirus structure and replication presented in this volume (see the chapters by E. Murphy and T. Shenk, Z. Ruzsics and U. Koszinowski, R. Kalejta, and G ...

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Nuclear Localization Sequences in Cytomegalovirus Capsid Assembly Proteins (UL80 Proteins) Are Required for Virus Production: Inactivating NLS1, NLS2, or Both Affects …

Yeast two-hybrid protein-protein interaction studies showed that HCMV pAP (pUL80.5) interacts with itself through a short sequence near its amino end called the amino-conserved domain (ACD) and with the major capsid protein (MCP; pUL86) through a short sequence at its carboxyl end called the carboxyl-conserved domain (see Fig. Fig.1) …

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The assembly protein precursor (pAP, pUL80.5; 38 kDa) and the related protease precursor (pPR, pUL80a; 74 kDa) ( Fig. 1) coordinate the capsid assembly process as self-interacting elements of an ...

Human cytomegalovirus capsid assembly protein precursor (pUL80.5) interacts with itself and with the major capsid protein (pUL86) through two different …

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The primary scaffolding components of cytomegalovirus, called the assembly protein precursor (pAP, pUL80.5) and the maturational protease precursor (pPR, pUL80a), …

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Scaffolding proteins of spherical prokaryotic and eukaryotic viruses have critical roles in capsid assembly. The primary scaffolding components of cytomegalovirus, called the assembly protein precursor (pAP, pUL80.5) and the maturational protease precursor (pPR, pUL80a), contain two nuclear localization sequences (NLS1 and NLS2), at least one of …

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PMC3067851. 10.1128/JVI.02663-10. We compared the full-length capsid maturational protease (pPR, pUL80a) of human cytomegalovirus with its proteolytic domain …

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